About Us
Led by a team with vast
experience in biopharmaceuticals, toxicology, botany, and emergency medicine,
ToxEM LLC is a pharmaceutical company committed to the development of drugs
derived from botanical sources that target life-threatening illnesses with high
impact to the public health.
ToxEM seeks to capitalize on
the opportunity created by the FDA upon issuance of its Guidance for
Industry-Botanical Drug Products which seeks to encourage and clarify the
development of new therapies from botanical sources.
ToxEM’s first drug product
(TXM-24631) targets a complex bleeding disorder, disseminated intravascular coagulopathy (DIC), a life-threatening
by-product of sepsis and a complication associated with a number of other acute
diseases. The main feature of DIC
is abnormal release of thrombin which leads to rampant clotting until clotting
factors are consumed. The result is unchecked bleeding. DIC complicates up to 60 % of cases of
severe sepsis, which is a significant cause of mortality in the United States,
and globally. Once contracted, DIC
increases mortality by up to 40%. Hence, an effective treatment for DIC in
sepsis should significantly decrease death rate from sepsis, especially if
given early in treatment. ToxEM’s product acts as an anti-coagulant
(antithrombotic) to prevent the abnormal clotting that characterizes DIC. DIC
complicates other diseases with high impact to public health such as trauma,
especially traumatic brain injury, and neoplasms. Moreover, its anti-coagulant
activity suggests potential follow-on indications for thromboembolic diseases
such as stroke, acute coronary syndromes, pulmonary embolism, and deep vein
thrombosis.
Mary E. Palmer, MD – Founder and Board Member
Dr Palmer is broadly
experienced in botany, emergency medicine, toxicology and environmental
conservation with particular focus on research and education. While Assistant
Endangered Species Botanist for NC Department of Agriculture, she initiated the
first comprehensive review of stewardship methods to monitor endangered plant
populations on selected conservation lands in the US. As Director/Research
Botanist for the Model Virginia Heritage Program for The Nature Conservancy
(TNC), she successfully ushered the program into permanency into VA state
government. In medicine she transferred her research interests into promotion
of evidence-based clinical standards through co-Chairing the Practice
Guidelines Committee of American Academy of Emergency Medicine (AAEM) as well
as by organizing international (Iceland 2002) and national educational
conferences at The George Washington University in 2004 and 2005. Blending
botany, medicine and toxicology, Dr. Palmer has authored publications on plant
toxicity including a multi-center study of adverse events associated with
dietary supplements which was published in The
Lancet. Dr. Palmer earned a BA from Kenyon College, an MS from The
University of Virginia, her MD from The George Washington University before
completing her residency in EM at the Medical College of Pennsylvania in
Philadelphia and fellowship training in Medical Toxicology at the NYC Poison
Control Center associated with NYU/Belleview Medical Centers. Dr. Palmer currently practices EM
part-time in the Washington metropolitan area.
Stephen N. Kirnon, Ed.D. – Business Advisor and Board Member
Dr. Stephen N. Kirnon joined ToxEM in 2008 as a business advisor and
board member. Dr. Kirnon has over
20 years of operational experience in biomedical organizations. Dr Kirnon was previously the President
and Chief Executive Officer of Pepgen Corporation, a biopharmaceutical company
based in Alameda, CA specializing in autoimmune diseases. He was formerly the President and CEO
of Target Protein Technologies, Inc., a pharmaceutical company based in San
Diego and specializing in the development of pharmaceutical compounds targeted
to specific tissues and organs of the human body. Prior to TPT, he was the President and COO and a member of
the Board of Yamanouchi Pharma Technologies, Inc., which is responsible for
developing and commercializing Yamanouchi’s proprietary drug delivery
technologies as well as the US development and manufacture of Yamanouchi’s
pharmaceuticals. Previously, he
was the President of the Drug Delivery Division of Cygnus, Inc., successfully
leading the Division into profitability and subsequently through sale of its
business. Dr. Kirnon has also held
various business development, sales, and marketing positions at Cygnus,
Biogenex, and SmithKline Beecham.
In addition to a B.A. degree in Biochemistry from Harvard University and
an MBA from Pepperdine University, Dr. Kirnon received his doctorate in
organization change and transformational leadership from Pepperdine University.
Palmer ME. Effect of Dietary Supplements
on Hemostasis: A Case of Bleeding in Context of Research and Surveillance.
Thromb Res. 2005;117(1-2):33-8; discussion 39-42. Epub 2005 Sep 22.
Palmer
ME, Haller C, McKinney PE et al. Adverse events associated with dietary
supplements: an observational study.
The Lancet 2003; 361: 101-106.
Smith
RA, Calviello CM, Der Marderosian A, Palmer ME. Evaluation of antibacterial
activity of Belizean Plants: An Improved Method. Pharmaceutical Biology 2000;38 (1):25-29.
Palmer ME. Kava’s (Piper methysticum)
methysticin: protection from strychnine and veratridine.(abstract). J Toxicol Clin Toxicol August 1999:37(5):609.
Palmer ME. A Gap in the Safety
Net: Results from A Multi-Center Prospective Study of Herbals and Other Dietary
Supplements (abstract) . J Toxicol
Clin Toxicol August 1999:37(5):610.
Rao RB, Hoffman RS, Desiderio
R, Raysor D, Palmer ME, Hung OL. Nicotinic toxicity from tincture of blue
cohosh (Caulophyllum thalictroides)
used as an abortifacient (abstract 68).
J Tox Clin Tox August 1998:36(5):455.
Palmer M, Nardi M, Gruber J et
al. Traditional Snake Bite Remedies from Belize Limit DIC in a Murine Model (abstract 184). J Toxicol Clin Toxicol.
1997;35(5):358.
Palmer M, Travis J, Antonovics
J. Temporal mechanisms influencing gender expression and pollen flow within a
self-incompatible perennial, Amianthium
muscaetoxicum (Liliaceae). Oecologia 1989;78:231-236.
Palmer M, Travis J, Antonovics
J. Seasonal pollen flow and progeny diversity in Amianthium muscaetoxicum (Liliaceae):
ecological potential for multiple-mating in a self-incompatible, hermaphrodite
perennial. Oecologia 1988;77:19-24.
Palmer M. A critical look at
rare plant monitoring in the United States. Biological Conservation
1987;39(2):113-127.
Palmer M. A survey of rare
plant monitoring in the United States: programs, regions and species priority.
Natural Areas Journal 1986;6(1):27-42.
Book Chapters and
Invited Review Articles:
Palmer ME, Betz JM. Plant
Toxicity. Goldfrank’s Toxicologic Emergencies, 7th 8th
and 9th editions,
NY. 2001, 2006, 2010 in press.
Palmer M. Poisonous Plants. Eds. Kazzi ZN, Roberge RJ. AAEM Toxicology Handbook. 2005; pp 123-134.
Palmer ME, Howland MA. Herbals and Dietary Supplements. In Clinical Toxicology, Ed. Ford M et al. W.B. Saunders, Philadelphia,
2000.
Palmer
ME. Toxicity of Herbals and Other Dietary Supplements. Emergency Medicine. September 1998.